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Hydration: A NEW PARADIGM
By Paul Harris, Ph.D.

Dehydration and Compensation Mechanisms - Part 6

The Three Stages of Water Regulation
The Multiple Role of Water
Dyspeptic Pain and Water
Low Back Pain & Water Uptake
Dehydration and Compensation Mechanisms
The Sleeper Phenomenon
How to Use Hydrate 1

Dehydration triggers a series of biochemical events that are the same as the body's response to stress. Dehydration produces stress, and subsequently actuates several strong hormones which "mop" up some of the water reserves of the body. This in turn will elicit further dehydration.

The body's reaction to stress is the "fight or flight" response, which in turn causes secretion of hormones. Initially, ACTH levels are increased with a consequent increase in cortisol secretion. Endorphins, cortisone, prolactin, vasopresssin, and rennin-angiotensin are also part of the hormonal crisis management team. Endorphin secretion is induced by stress, and prepares the body for impending danger or hardship. Endorphins also increase the body's pain threshold.

Cortisone: Hydrocortisone, 17-hydroxy corticosteroid, 17-OHCS is a hormone secreted by the adrenal cortex. The raw material for cortisol is cholesterol. Exogenous cholesterol in normal conditions accounts for 80 percent of the total cortisol production, and 20 percent synthesized the body's store of raw materials, such as fat, and protein for energy conversion-and synthesis of extra neurotransmitters.

Prolactin: Prolactin is similar to growth hormones due to its specific action on tissues. It also has no regulatory effect on a secondary endocrine gland. The only established function of prolactin in man is the initiation and maintenance of lactation…even if there is dehydration. Although the nutritional components of milk are indeed important, the water content is of primary importance to the developing fetus. During mitosis, a single cell gives rise to a daughter cell and 75 percent or more of its volume requires water. Hydration of the daughter cell enables it to access its other dissolved contents.

Dr. Batmanghelidj alludes to a study conducted on mice that revealed when prolactin was increased, there was an increase in mammary tumors. He believes that due to the similarity of prolactin to growth hormone---there is more than a causal relationship to chronic dehydration persistent prolactin secretion, and tumor production in the breast.

Vasopressin: Vasopressin has a regulatory action on the bio-availability of water in some cells of the body. It also has a vasoconstrictive effect on the capillaries it activates. The architecture of the cell membrane is bilayer. The adhesive property of water is partially responsible for cell wall integrity. According to Dr. Batmanghelidj, enzymes travel and perform their varied functions in a connecting passageway located between the bilayers of the cell membrane.

He characterizes this waterway as a "water filled beltway." The body has a unique safeguard against significant water loss in the beltway. Dr. Batmanghelidj states, "The vasopresssin receptor converts to a 'showerhead' structure when vasopresssin hormone reaches the cell membrane and fuses with its specially designed receptor." Vasopressin plays a key role in water management, and rationing in dehydration.

Rennin-Angiotensin system: This system is a primary regulator of aldosterone, which is produced by the zone glomerulosa. The juxtaglomerular apparatus of the nephron is responsible for the release of rennin (an enzyme) into the general circulation. Rennin-angiotensin (RA) plays a crucial role in water regulation, and is a subordinate mechanism to histamine activation in the brain.

The (RA) system is extremely sensitive to decreased levels of fluid volume in the body, and sodium depletion. The (RA) system is also responsible for vasoconstrictive action on the capillary bed, and the vascular system. This system is largely responsible for restoration of fluid volume in the body. Adequate hydration is essential since hypertension can occur from prolonged (RA) activity.

The Three Stages of Water Regulation
The Multiple Role of Water
Dyspeptic Pain and Water
Low Back Pain & Water Uptake
Dehydration and Compensation Mechanisms
The Sleeper Phenomenon
How to Use Hydrate 1

 


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